Fulvic acid is a family of organic acids. The term “ fulvic
acid” is understood by those of skill in the art, as exemplified by U.S.
Pat. Nos. 6,874,277, 6,596,900, 6,478,946, and 5,204,368, the contents
of the entirety of each of which are hereby incorporated herein by reference.
Although fulvic acid has been studied extensively in the fields of geochemistry,
agriculture, and environmental chemistry, it is still not widely known
by scientists in the medical and nutritional fields. Fulvic acid is not
one specific compound. Rather, it is a large family of related organic
compounds. The term, fulvic acid, is similar to the terms amino acids or
tannic acids. There are 20 different acids known as amino acids that share
similar chemical structures, characteristics and biological functions.
Tannic acids are polyphenols derived from plants. There are probably hundreds
if not thousands of different compounds in the family of tannic acids.
Fulvic acids are quite the same in principal. No one knows exactly how
many compounds exist within this family of humus derived compounds. In
a recent publication, one researcher isolated 4,000 distinct compounds
in just one sample of Suwanee River fulvic acid. In addition, fulvic acids
derived from aquatic sources are distinct from those isolated from coals
or soils (Stevenson, 1994). There can be little doubt, that there are at
least several thousand different compounds that are included in the family
of fulvic acid.
Fulvic acids, as referred to herein, are the organic acids
fraction that is soluble in water under all pH conditions and is in general
lower in molecular size and weight and lower in color intensity than humic
acids. Fulvic acids are yellow to orange in color when dissolved in water
at concentrations of 50 to 500 milligrams per liter. Further, fulvic acids
may be defined as the class of compounds which are purified by the standard
methods promulgated by the International Humic Substances Society (IHSS)
and as outlined in Examples 1 and 2 below.
According to certain embodiments of the present invention,
the fulvic acid may be purified or substantially purified before incorporation
into a composition for human use or before use in a method to promote hair
growth. In certain embodiments, the fulvic acid may be that obtained via
purification using XAD-8. In other embodiments of the present invention,
the fulvic acid is isolated from an aquatic source. In further embodiments
of the present invention, the fulvic acid is not isolated from peat, shilajit,
or coal. Further, the fulvic acid may be fulvic acid other than oxifulvic
According to one embodiment of the present invention,
a composition for human use containing fulvic acid is provided. The composition
comprises at least 700 mg/L fulvic acid and preferably between 700 and
20,000 mg/L fulvic acid. Exemplary forms of these compositions include,
but are not limited to, tablets, capsules, granules, supplements, foods,
creams, ointments, emulsions, suspensions, liquids, drinks, beverages,
sprays, inhalers, suppositories, drops, cosmetics, or other forms designed
to deliver fulvic acid to a subject.
The composition for human use may be in the form of a
cosmetic. Such cosmetics are exemplified by, but not limited to, lotions,
milky lotions, creams, facial packs, ointments, tooth pastes, bathing agents,
bath detergents, facial cleansing agents, hair lotions, hair-care compositions,
or shampooing agents. Cosmetics of the present invention may be prepared
in accordance with a conventional method, and those usually used in cosmetics
such as hydrocarbons, waxes, fats and oils, esters, higher fatty acids,
higher alcohols, surfactants, perfume, pigments, anticorrosive agents,
antioxidants, ultraviolet absorbents, alcohols, pH adjustment agents, various
ingredients with medicinal effect can be properly selected and formulated.
In addition, such cosmetics may comprise a component having skin cosmeticizing
action such as, but not limited to, retinoic acid, ?-hydroxy acid, retinol,
glycerol, polyethylene glycol, potassium hydroxide, triethanolamine, and
other saccharides. The cosmetic may further comprise a component having
a hair restoring action including, but not limited to, minoxidil, calpronium
chloride, heparin analogs, glyceryl monolinolate, linoleic acid, various
crude drug extracts, and the like. The cosmetics of the present invention
may be prepared by comprising, adding and/or diluting a composition containing
fulvic acid so as to achieve a final concentration of at least 700 mg/L