The silver lining is that finding a treatment that could delay onset could reduce the number of individuals with Alzheimer's disease by nearly 50 percent. In this context certain herbal combination Shilajit and Withania Somnifera show surprising results on Alzheimer's patients. They have been found to boost memory and enhance cognition in Alzheimer's patients. Shilajit is a mineral pitch found in Himalayan mountains and Withania Somnifera also known as Indian ginseng is a herb found in India. Withania somnifera has proven memory boosting effects and is also known to boost stamina. 

Systemic administration of Shilajit & Withania Somnifera combination for enhancing cognition in Alzheimer's patients 

Following is the details of research done by Scientists Schliebs R.; Liebmann A.; Bhattacharya S.K.; Kumar A.; Ghosal S.; Bigl V. and R. Schliebs  at Paul Flechsig Institute Brain Res., Department of Neurochemistry, University of Leipzig, D-04109 Leipzig, Germany.
 

 " Although some promising results have been achieved by acetyl cholinesterase inhibitors, an effective therapeutic intervention in Alzheimer's disease still remains an important goal. Sitoindosides VII-X, and withaferin-A, isolated from aqueous methanol extract from the roots of cultivated, varieties of Withania somnifera (known as Indian Ginseng  -  ASHWAGANDHA ), as well as SHILAJIT, a pale-brown to blackish brown exudation from steep rocks of the Himalayan mountain, are used in Indian medicine to attenuate cerebral functional deficits, including amnesia, in geriatric patients. The present investigation was conducted to assess whether the memory enhancing effects of plant extracts from Withania somnifera and Shilajit are owing to neurochemical alterations of specific transmitter systems. Therefore, histochemistry to analyze acetyl cholinesterase activity as well as receptor auto radiography to detect cholinergic, glutamatergic and GABAergic receptor subtypes were performed in brain slices from adult male Wistar rats, injected intraperitoneally daily with an equimolar mixture of sitoindosides VII-X and withaferin-A (prepared from Withania somnifera) or with Shilajit, at doses of 40 mg/kg of body weight for 7 days. 

Administration of Shilajit led to reduced acetyl cholinesterase staining, restricted to the basal forebrain nuclei including medial septum and the vertical limb of the diagonal band. 

Systemic application of the defined extract from Withania somnifera, however, led to differential effects on AChE activity in basal forebrain nuclei: slightly enhanced AChE activity was found in the lateral septum and globus pallidus, whereas in the vertical diagonal band AChE activity was reduced following treatment with sitoindosides VII-X and withaferin-A. These changes were accompanied by enhanced M1-muscarinic cholinergic receptor binding in lateral and medial septum as well as in frontal cortices, whereas the M2-muscarinic receptor binding sites were increased in a number of cortical regions including cingulate, frontal, piriform, parietal acid retrosplenial cortex. 

Treatment with Shilajit or the defined extract from Withania somnifera affected neither GABA(A) and benzodiazepine receptor binding nor NMDA and AMPA glutamate receptor subtypes in any of the cortical or sub cortical regions studied. 

The data suggest that Shilajit and the defined extract from Withania somnifera affect preferentially events in the cortical and basal forebrain cholinergic signal transduction cascade. 

The drug induced increase in cortical muscarinic Acetylcholine receptor capacity might partly explain the cognition enhancing and memory improving effects of extracts from Withania somnifera observed in animals and humans.
 

Contact   Details  at  Department of Neurochemistry, University of Leipzig

Paul Flechsig Institute of Brain Research
Department of Neurochemistry
Jahnallee 59
04109 Leipzig
GERMANY
Director: Prof. Dr. Volker Bigl
Fon: +49 (0) 341 97 25 701
Fax: +49 (0) 21 14 492
 

Are any of your near & dear ones ... someone you care suffering from or showing signs of Alzheimer's disease, age related memory loss, decrease in mental function  or dementia? We strongly recommend taking a 4 months course of Shilajit and Withania Somnifera. 

As such anyone can take this combination for it's memory and stamina boosting effects. Shilajit (Fulvic acid) is a known anti aging elixir. Shilajit and Withania Somnifera combination serve as a powerful nervine & cerebral tonic fortifying brain cells against degeneration. This combination can surely prevent the onset of any brain degenerative disease like Alzheimer's, Parkinson's, dementia etc.
 
 
 
 

This combination has been proven to be very effective in preventing, arresting and reversing Alzheimer's and Parkinson's conditions.

4 Packets of Shilajit & 4 Bottles of Withania Somnifera- 4 Months Course – U.S.$84 ( includes free Shipping worldwide)

           U.S.$ 84    ( Free shipping worldwide)
 

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